Impact of leg bending in the patient-specific computational fluid dynamics of popliteal stenting

Abstract Endovascular treatment of the femoro-popliteal artery has recently become a valuable therapeutic option for popliteal arterial aneurysms. However, its efficacy remains controversial due to relatively high rate complications, such as stent occlusion result intra-stent thrombosis. The elucidation interplay among vessel geometrical features, local hemodynamics, and leg bending seems crucial understand onset progression To this aim, patient-specific computational fluid dynamic simulations were performed in order assess hemodynamics two patients endovascularly treated aneurysm by stent-grafts experiencing Both Newtonian non-Newtonian blood rheological models considered. Results presented terms tortuosity, luminal area exposed low (< 0.4 Pa) (> 1.5 time-averaged wall shear stress (TAWSS), 0.3) oscillatory index (OSI), flow helicity. Study outcomes demonstrated that induced significant hemodynamic differences 50% increase) both all considered variables, except OSI one patients. In configurations, stent-graft overlapping severe discontinuity lumen diameter where proximal stented zone is characterized velocity, helicity, TAWSS, OSI; while distal part higher lower OSI. Sensitivity study on applied boundary conditions showed different inlet velocity profiles given waveform affect slightly numerical solution; conversely, shape magnitude prescribed determinant. Focusing comparison between models, with TAWSS greater model patients, no difference occurs surfaces TAWSS. GraphicAbstract Patient-specific straight bent (OSI);